Inactive X chromosome has the highest concentration of unmethylated Hha I sites.
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چکیده
منابع مشابه
BRCA1 Supports XIST RNA Concentration on the Inactive X Chromosome
BRCA1, a breast and ovarian tumor suppressor, colocalizes with markers of the inactive X chromosome (Xi) on Xi in female somatic cells and associates with XIST RNA, as detected by chromatin immunoprecipitation. Breast and ovarian carcinoma cells lacking BRCA1 show evidence of defects in Xi chromatin structure. Reconstitution of BRCA1-deficient cells with wt BRCA1 led to the appearance of focal ...
متن کاملStructural aspects of the inactive X chromosome
A striking difference between male and female nuclei was recognized early on by the presence of a condensed chromatin body only in female cells. Mary Lyon proposed that X inactivation or silencing of one X chromosome at random in females caused this structural difference. Subsequent studies have shown that the inactive X chromosome (Xi) does indeed have a very distinctive structure compared to ...
متن کاملChromatin Structure of the Inactive X Chromosome
X-inactivation is the unusual mode of gene regulation by which most genes on one of the two X chromosomes in female mammalian cells are transcriptionally silenced. The underlying mechanism for this widespread transcriptional repression is unknown. This thesis investigates two key aspects of the X-inactivation process. The first aspect is the correlation between chromatin structure and gene expr...
متن کاملThe facultative heterochromatin of the inactive X chromosome has a distinctive condensed ultrastructure.
The mammalian inactive X chromosome (Xi) is a model for facultative heterochromatin. Increased DNA compaction for the Xi, and for facultative heterochromatin in general, has long been assumed based on recognition of a distinct Barr body using nucleic-acid staining. This conclusion has been challenged by a report revealing equal volumes occupied by the inactive and active X chromosomes. Here, we...
متن کاملGenetic and pharmacological reactivation of the mammalian inactive X chromosome.
X-chromosome inactivation (XCI), the random transcriptional silencing of one X chromosome in somatic cells of female mammals, is a mechanism that ensures equal expression of X-linked genes in both sexes. XCI is initiated in cis by the noncoding Xist RNA, which coats the inactive X chromosome (Xi) from which it is produced. However, trans-acting factors that mediate XCI remain largely unknown. H...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1988
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.85.20.7657